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Muzlifah Haniffa

Muzlifah Haniffa malayziyalik dermatolog va immunolog boʻlib, u immunitet tizimini rivojlantirishga va biologiyani tushunish uchun bir hujayrali usullardan foydalanishga asosiy eʼtiborini qaratgan edi. Haniffa professor va Newkasl universiteti tibbiyot fanlari fakultetining Wellcome Trustda katta ilmiy xodimi boʻlib faoliyat olib boradi[1][2].

Avvalgi hayoti va taʼlimi tahrir

Haniffa Malayziyaning Penang shahrida tugʻilgan[3]. Bolaligida uning ilm-fanga boʻlgan qiziqishi dastlab kosmos tomonga boʻlgan qiziqishdan keyin uygʻongan, ammo keyinchalik u klinik olim sifatida faoliyatini davom ettirishga qaror qildi[2]. Haniffa Serembandagi Tunku Kurshiah kollejida tahsil olgan va 1990-yillarda Buyuk Britaniyaga ko‘chib o‘tgan[4]. Haniffa 1999-yilda Wels universiteti tibbiyot kollejining BSc, MBBCh fakultetini tamomlagan. 2002-yilda u Qirollik shifokorlar kollejiga aʼzo boʻldi. 2007-yilda u London gigiena va tropik tibbiyot maktabining epidemiologiya boʻyicha diplomini qoʻlga kiritdi[1]. U 2009-yilda Newkasl universitetida doktorlik dissertatsiyasini tamomlagan va 2010-yilda klinik dermatologiya bo‘yicha treningni tugatgan[1]. U Tibbiy tadqiqotlar kengashining 2009-yilda Sue Makkarti mukofoti sovrindori boʻlgan[1].

Faoliyati tahrir

2013-yilda Yevropa dermatologiya tadqiqot jamiyati tadqiqoti uchun Haniffaga Kumush mukofotni topshirgan[1]. U STEM nominatsiyasida 2016-yilning shimoliy-sharqidagi „Yil tadbirkor ayoli“ mukofotlari uchun nomzodlar ro‘yxatiga kiritilgan[5]. 2016-yilda uning oq qon hujayralari funksiyalari boʻyicha tadqiqotlari Lister Profilaktik Tibbiyot Instituti tomonidan 200,000 funt sterling miqdoridagi stipendiya tufayli kuchaytirildi[3][2][4].

Dendritik hujayralar tahrir

Haniffaning immun tizimi ustidagi ishi inson terisida dendritik hujayralar deb hisoblangan (CD14 mavjudligi bilan belgilanadigan) populyatsiyasi aslida makrofaglar ekanligini aniqlash va sichqonlarda dendritik hujayralar kichik toʻplami mavjudligini koʻrsatadigan tadqiqotlarni oʻz ichiga oladi, qoʻziqorin infeksiyasiga qarshi yordamchi 17 hujayra hisobida tekshiriladi[6][7]. Haniffa 5-Immunologiya boʻyicha Yevropa Kongressi tomonidan 2018-yilda Allerlologiya boʻyicha „Erta Karyera“ mukofotiga sazovor boʻldi[8].

Transkriptomik usullar tahrir

Haniffa Sara Teichmann, Fiona Powrie, Ashley Moffett va boshqalar bilan bir qatorda bir hujayrali transkriptomik usullardan foydalangan holda inson tanasidagi barcha hujayralarni tavsiflashni maqsad qilgan Inson Hujayra Atlasining aʼzosi sanaladi[9][10][11]. 2018-yilda uning laboratoriyasi mutatsiyaga uchragan va buyrak saratonini keltirib chiqaradigan buyrak hujayralarining asosiy qismini aniqlashga hissa qoʻshdi. Bu buyrak karsinomasi hujayralarining biologik tarkibini berilgan sogʻlom buyrak hujayralariga moslashtirish orqali amalga oshirildi[12][13][14]. Shundan soʻng platsentaning bir hujayrali tadqiqoti oʻtkazildi, u desiduada yangi hujayra sub-tiplarini topdi, bu ona va homila immun tizimlarining bir-biri bilan oʻzaro taʼsiri va homiladorlik yoki preeklampsidan qanday qochishini tushunishga yordam berdi[15][16][17].

68 million dollar sarmoya tahrir

Tadqiqotda Inson taraqqiyoti biologiyasi resursidan 70 000 ta hujayra va toʻqimalar ishlatilgan[15]. Bundan tashqari, Haniffa va uning hamkorlari tugʻma va adaptiv immunitet tizimi, jumladan tartibga soluvchi T hujayralari, dendritik hujayralar va monotsitlar boʻyicha bir hujayrali tadqiqotlarni nashr etdilar[18][19][20][21]. 2019-yilda Chan Sukerberg tashabbusi Inson Hujayralari Atlasini rivojlantirishga grant sifatida 68 million dollar sarmoya kiritayotganini, shu jumladan Haniffaga immun tizimi va jigarni qarish davrida bir hujayrali batafsil o‘rganish uchun mukofotlar berishini eʼlon qildi[22][23][24].

Manbalar tahrir

  1. ↑ 1,0 1,1 1,2 1,3 1,4 „Professor Muzlifah Haniffa“. Newcastle University. Qaraldi: 2022-yil 10-iyun.
  2. ↑ 2,0 2,1 2,2 Albakri. „Penang-born scientist receives RM1.09mil for work on white blood cells - Nation | The Star Online“. www.thestar.com.my. Qaraldi: 2019-yil 14-iyul.
  3. ↑ 3,0 3,1 Reporters. „Penang-born scientist gets RM1m UK research award“. Free Malaysia Today (2016-yil 11-sentyabr). Qaraldi: 2019-yil 14-iyul.
  4. ↑ 4,0 4,1 Ruxyn. „This Malaysian Received A Prestigious Research Prize For Her Outstanding Scientific Work“. SAYS.com (2016-yil 8-sentyabr). Qaraldi: 2019-yil 14-iyul.
  5. ↑ Whitfield. „Top businesswomen shortlisted in North East Woman Entrepreneur of the Year Awards“. nechronicle (2016-yil 5-oktyabr). Qaraldi: 2019-yil 14-iyul.
  6. ↑ „Discovery of a new class of white blood cells uncovers target for better vaccine design“. ScienceDaily. Qaraldi: 2019-yil 14-iyul.
  7. ↑ Haniffa, Muzlifah; Collin, Matthew; Ginhoux, Florent; Bigley, Venetia; Poidinger, Michael; Duan, Kaibo; Wasan, Pavandip Singh; Larbi, Anis et al. (2014-09-18). "Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages" (English). Immunity 41 (3): 465–477. doi:10.1016/j.immuni.2014.08.006. ISSN 1074-7613. PMID 25200712. PMC 4175180. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4175180. 
  8. ↑ „Award Ceremonies“. ECI 2018. Qaraldi: 2019-yil 14-iyul.
  9. ↑ „Human Cell Atlas: we're funding scientists at six UK research institutes | Wellcome“. wellcome.ac.uk. Qaraldi: 2019-yil 14-iyul.
  10. ↑ „Human Cell Atlas Takes First Steps Towards Understanding Human Development“. Cell Science from Technology Networks. Qaraldi: 2019-yil 14-iyul.
  11. ↑ Regev, Aviv; Teichmann, Sarah A; Lander, Eric S; Amit, Ido; Benoist, Christophe; Birney, Ewan; Bodenmiller, Bernd; Campbell, Peter et al. (2017-12-05) "The Human Cell Atlas" eLife 6 doi:10.7554/eLife.27041 ISSN 2050-084X PMID 29206104. 
  12. ↑ „New hope for patients with kidney cancer“. The Northern Echo. Qaraldi: 2019-yil 14-iyul.
  13. ↑ Behjati, Sam; Clatworthy, Menna; Teichmann, Sarah A.; Haniffa, Muzlifah; Coleman, Nicholas; Sebire, Neil; Stewart, Grant D.; Warren, Anne Y. et al. (2018-08-10) "Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors" Science 361 (6402): 594–599 doi:10.1126/science.aat1699 ISSN 0036-8075 PMID 30093597 PMC 6104812 //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6104812. 
  14. ↑ „Single-Cell Transcriptome Atlas Elucidates Features Shared by Cancerous, Normal Kidneys“. GenomeWeb. Qaraldi: 2019-yil 14-iyul.
  15. ↑ 15,0 15,1 „Human cell atlas study reveals maternal immune system modifications in early pregnancy: Cell map of healthy pregnancy could also help understand miscarriages or pre-eclampsia“. ScienceDaily. Qaraldi: 2019-yil 14-iyul.
  16. ↑ Teichmann, Sarah A.; Moffett, Ashley; Haniffa, Muzlifah; Stubbington, Michael J. T.; Wright, Gavin J.; Bulmer, Judith N.; Rowitch, David H.; Filby, Andrew et al. (November 2018). "Single-cell reconstruction of the early maternal–fetal interface in humans". Nature 563 (7731): 347–353. doi:10.1038/s41586-018-0698-6. ISSN 1476-4687. PMID 30429548. https://eprint.ncl.ac.uk/fulltext.aspx?url=253209/5307C9D4-195F-4436-8401-914EEFAD7198.pdf&pub_id=253209. 
  17. ↑ „The Very First Human Cell Atlas Study of Early Pregnancy“. Cell Science from Technology Networks. Qaraldi: 2019-yil 14-iyul.
  18. ↑ Miragaia, Ricardo J.; Gomes, Tomás; Chomka, Agnieszka; Jardine, Laura; Riedel, Angela; Hegazy, Ahmed N.; Whibley, Natasha; Tucci, Andrea et al. (February 2019). "Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation". Immunity 50 (2): 493–504.e7. doi:10.1016/j.immuni.2019.01.001. PMID 30737144. PMC 6382439. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6382439. 
  19. ↑ See, Peter; Dutertre, Charles-Antoine; Chen, Jinmiao; Günther, Patrick; McGovern, Naomi; Irac, Sergio Erdal; Gunawan, Merry; Beyer, Marc et al. (2017-06-09). "Mapping the human DC lineage through the integration of high-dimensional techniques". Science 356 (6342): eaag3009. doi:10.1126/science.aag3009. ISSN 0036-8075. PMID 28473638. PMC 7611082. https://eprint.ncl.ac.uk/fulltext.aspx?url=238281/D7CF6814-09D4-49DE-A0D6-25218B11EB81.pdf&pub_id=238281. 
  20. ↑ Villani, Alexandra-Chloé; Satija, Rahul; Reynolds, Gary; Sarkizova, Siranush; Shekhar, Karthik; Fletcher, James; Griesbeck, Morgane; Butler, Andrew et al. (2017-04-21). "Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors". Science 356 (6335): eaah4573. doi:10.1126/science.aah4573. ISSN 0036-8075. PMID 28428369. PMC 5775029. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5775029. 
  21. ↑ Hagai, Tzachi; Chen, Xi; Miragaia, Ricardo J.; Rostom, Raghd; Gomes, Tomás; Kunowska, Natalia; Henriksson, Johan; Park, Jong-Eun et al. (November 2018). "Gene expression variability across cells and species shapes innate immunity". Nature 563 (7730): 197–202. doi:10.1038/s41586-018-0657-2. ISSN 0028-0836. PMID 30356220. PMC 6347972. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6347972. 
  22. ↑ www-core (webteam). „Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute“. www.sanger.ac.uk. Qaraldi: 2019-yil 14-iyul.
  23. ↑ „An Integrated Map of the Immune System in Humans Across Tissues and Ages“. Chan Zuckerberg Initiative. Qaraldi: 2019-yil 14-iyul.
  24. ↑ „A Reference Cell Atlas of Human Liver Diversity Over a Lifespan“. Chan Zuckerberg Initiative. Qaraldi: 2019-yil 14-iyul. 
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