1,4-laktonaza
1,4- laktonaza fermenti (EC 3.1.1.25) umumiy reaksiyani katalizlaydi.
- a 1,4-lakton + H 2 O 4-gidroksi kislota
Bu ferment gidrolazalar oilasiga, xususan, karboksilik ester aloqalariga ta'sir qiluvchi fermentlarga tegishli. Tizimli nomi 1,4-lakton gidroksiasilhidrolazdir. U g-laktonaza deb ham ataladi. Galaktoza almashinuvida, askorbat va aldarat metabolizmida ishtirok etadi. U bitta kofaktorni, Ca 2+ ni ishlatadi.
Strukturaviy tadqiqotlar tahrir
2007-yil oxiriga kelib, ushbu fermentlar sinfi uchun PDB kirish kodlari 2DG0, 2DG1 va 2DSO bilan uchta tuzilma hal qilinadi.
Ilovalar tahrir
Chen va boshqalar tomonidan o'tkazilgan tadqiqotda 1,4-laktonase E. coli ifodalangan va chiral birikmalarning assimetrik sintezi uchun yuqori samarali biokatalizator sifatida ishlatilgan[1].
Ma'lumotnomalar tahrir
- ↑ Chen, Bing; Fan, Li-Qiang; Xu, Jian-He; Zhao, Jian; Zhang, Xian; Ouyang, Li-Ming (October 2010). "Biocatalytic properties of a recombinant Fusarium proliferatum lactonase with significantly enhanced production by optimal expression in Escherichia coli". Applied Biochemistry and Biotechnology 162 (3): 744–756. doi:10.1007/s12010-009-8819-1. ISSN 1559-0291. PMID 19876606. https://pubmed.ncbi.nlm.nih.gov/19876606/.
- "Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase". J. Biol. Chem. 241 (21): 4835–41. 1966. PMID 4958984.
- "Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. II. Metal ion effects, kinetics, and equilibra". J. Biol. Chem. 241 (21): 4842–7. 1966. PMID 4958985.