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Fayl:HIF Nobel Prize Physiology Medicine 2019 Hegasy ENG.png

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English: Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis.
Sanasi
Manba Oʻzimning ishim
Muallif Dr. Guido Hegasy

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Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability

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tasvirlangan ob'ekt

tashkil etilgan

8 Oktyabr 2019

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joriy12:07, 9-Oktyabr 201912:07, 9-Oktyabr 2019 dagi versiya uchun tasvir3 508 × 2 480 (1,26 MB)Guido4Typo corrected, changed some colors
16:06, 8-Oktyabr 201916:06, 8-Oktyabr 2019 dagi versiya uchun tasvir3 508 × 2 480 (1,26 MB)Guido4User created page with UploadWizard

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