Somatotropinlar tipik vakili somatotrop boʻlgan oqsillar guruhi hisoblanadi, shuningdek, organizm oʻsishida muhim rol oʻynaydigan o`sish gormoni sifatida tanilgan[1]. Bu guruhning boshqa aʼzolariga laktogen va uning yoʻldosh analogi -prolaktin (yoʻldoshda prolaktinga bogʻliq boʻlgan oqsillarni va sut bezida laktatsiyani ragʻbatlantiradi)[2], proliferin, proliferinga bogʻliq boʻlgan oqsillar[3] va turli xil baliqlarda uchraydigan somatolaktin[4][5] kiradi. Qoramol somatotropining 3D tuzilishi energiyani kamaytirish usullarining kombinatsiyasi yordamida bashorat qilingan.

Bu guruhdan odamda uchraydigan peptidlar

tahrir

CSH1, CSH2, CSHL1, OʻG1; OʻG2, PRL

Manbalar

tahrir
  1. Wallis M (1981). "The molecular evolution of pituitary growth-hormone prolactin and placental-lactogen - a protein family showing variable rates of evolution". J. Mol. Evol. 17: 10–18. doi:10.1007/bf01792419. 
  2. "A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta". Biochemistry 28 (12): 5154–5161. 1989. doi:10.1021/bi00438a036. PMID 2765528. 
  3. "Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily". Biochim. Biophys. Acta 1009 (1): 75–82. 1989. doi:10.1016/0167-4781(89)90081-X. PMID 2790033. 
  4. "Cloning of somatolactin alpha, beta forms and the somatolactin receptor in Atlantic salmon: seasonal expression profile in pituitary and ovary of maturing female broodstock". Reprod. Biol. Endocrinol. 6: 42. 2008. doi:10.1186/1477-7827-6-42. PMID 18793397. PMC 2553077. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2553077. 
  5. Benedet Perea, Susana (2008). Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon. (Ph. D.) Department of Zoology/Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden